2,3-dinor-6-keto-PGF1 alpha Affinity Resin CAS NO.64700-71-6

Prostacyclin (PGI2) is involved in platelet aggregation, vasoconstriction, and reproductive functions. PGI2 has a half life of 60 minutes in plasma bu…

Prostacyclin (PGI2) is involved in platelet aggregation, vasoconstriction, and reproductive functions. PGI2 has a half life of 60 minutes in plasma but only 2 to 3 minutes in buffer. The production of PGI2 is typically monitored by measurement of 6-keto-PGF1 alpha and 2,3-dinor-6-keto-PGF1 alpha. 6-keto-PGF1 alpha is produced by thenon-enzymatic hydration of PGI2, and is further metabolized in urine to the 2,3-dinor derivative. A number of pharmaceuticals alter and/or inhibit the synthesis of PGI2. Methods to measure PGI2 in urine typically involve HPLC, gas chromatography/mass spectrometry or radioimmunoassay and enzyme immunoassay for 6-keto-PGF1 alpha.